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Scientific Research

Stay apprised of findings from across the field with summaries of research published in SfN journals, and learn about rigor, responsible conduct of research, and other topics important to the scientific community.
L5 targets a wide range of thalamic nuclei and extrathalamic nuclei, although specific targets vary across injection site. Prasad et al. JNeurosci. 2020; 40(30):5785-5796, Figure 8.
Scientific Research
Layer 5 of Neocortex Gives Rise to Diverse Corticofugal Pathways
The ClaustrumClassifier (ClaCla): a neural-network assisted cell classification tool. A trained neural network developed to facilitate the classification of claustral neurons in four steps. Step 1, Input raw data file. Step 2, Automated extraction of intrinsic electrical properties. Step 3, Neuronal network assisted cell classification. Step 4, The classifier returns the likelihood that the classified cell belongs to one of the eight cell subtypes.
Scientific Research
Claustrum Neurons Go To Unexpected Places. Here’s How to Find Them
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  • TrAC permits fluorescent labeling of genetically defined neuron populations based on axonal projections. Schematic diagrams show a simple version of TrAC using two recombinases and a dual-recombinase-responsive fluorescent indicator allele. Fluorescent labeling is restricted to neurons expressing recombinase A which project to the brain region injected with the retrograde-transported virus encoding recombinase B.
    Novel Viral-Genetic Method for Tracing Axon Collaterals of Broadly Projecting Neurons
  • The ClaustrumClassifier (ClaCla): a neural-network assisted cell classification tool. A trained neural network developed to facilitate the classification of claustral neurons in four steps. Step 1, Input raw data file. Step 2, Automated extraction of intrinsic electrical properties. Step 3, Neuronal network assisted cell classification. Step 4, The classifier returns the likelihood that the classified cell belongs to one of the eight cell subtypes.
    Claustrum Neurons Go To Unexpected Places. Here’s How to Find Them
  • This image shows a neuroprogenitor culture used to study the effect of the phagocytic microglial secretome. Nuclei are shown in white (DAPI), progenitors in green (nestin), astrocytes in red (GFAP) and neuroblasts in magenta (doublecortin). Image credits: Irune Diaz-Aparicio.
    Exploring Recent Discoveries in Neuroscience Research
    October 26, 2020 2:00 PM - 3:00 PM EDT
  • L5 targets a wide range of thalamic nuclei and extrathalamic nuclei, although specific targets vary across injection site. Prasad et al. JNeurosci. 2020; 40(30):5785-5796, Figure 8.
    Layer 5 of Neocortex Gives Rise to Diverse Corticofugal Pathways
  • This image shows a parvalbuminexpressing inhibitory basket cell (green) in the hippocampus of an amyloid-depositing 5xFAD mouse. The cell has been morphologically reconstructed after patch clamp recording of spontaneous synaptic activity during sharp wave ripple events. Non-patched parvalbumin neurons are labeled in red.
    The Human Brain Tracks Speech More Closely in Time Than Other Sounds
  • The Neuroscience of Gaming
  • This image shows phosphorylated (inactivated) cofilin (red) in spinal cord. Phosphorylated cofilin is present at high levels in in a broad swathe of embryonic spinal neurons (green), including motor neurons (blue).
    Revealing a Sexually Differentiated Neural Circuit for Sensing Social Stimuli
  • A poster presenter explaining his research to an annual meeting attendee
    How SfN's Founding Hopes Still Fuel Goals for the Next 50 Years
  • Sebnum Tuncdemir accepts the Nemko Prize in Cellular or Molecular Neuroscience.
    A Postdoc Reflects Back on the Ups and Downs of Her Thesis Research
  • Map of "the smell network."
    The Smell Network: The Brain’s Architecture for Human Olfaction
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    Neuroethics Meets Artificial Intelligence
  • Figure 1: Microbiome depletion alters how the brain responds to opioids. Microbiome intact animals in the intoxication state (left) exhibited increases in neuronal recruitment (green arrows) in the basolateral amygdala (BLA), while the central amygdala (CeA), periaqueductal gray (PAG), and locus coeruleus (LC) do not exhibit increases (blue dash) compared to control animals. During withdrawal, microbiome intact animals exhibit increased recruitment of the CeA and lateral habenula (LHB) compared to control animals. Microbiome depleted animals (right) exhibit a reduction of recruitment in the BLA, and increases in the CeA, PAG, and LC in the intoxication state compared to intact animals. Additionally, microbiome depleted animals in the withdrawal state exhibit a decrease in the CeA and an increase in recruitment in the Lateral Habenula (LHB) compared to intact animals.
    Depletion of the Microbiome Changes How the Brain Responds to Opioids
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