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Scientific Research

Stay apprised of findings from across the field with summaries of research published in SfN journals, and learn about rigor, responsible conduct of research, and other topics important to the scientific community.
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Scientific Research
Analyzing Circuits With Extracellular Recording and Optogenetics
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Are Fish Hippocampal-Like Networks Functionally Similar to Their Mammalian Counterparts?
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  • The Betti-0 curve. A, Two-dimensional toy example: a set of 15 nodes, four filtration values ε, represented as the circle diameter and their corresponding Betti-0 (B0). B, Betti-0 curve for a hypothetical brain network; each point in the curve represents the B0 for each filtration value. In both cases, at ε = 0 the number of components is equal to the number of nodes, n. As the filtration value increases, the number of components reduces, and eventually will reach a single one containing all nodes. Brain views generated with brain-net (Xia et al., 2013), r stands for Pearson’s correlation.
    Exploring Individual Brain Connectomes With Topological Data Analysis in ADHD
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    Cortical and Hippocampal Contributions Throughout Skill Learning in Mice
  • Extracting spatial heterogeneity of AMPA receptor content within functional zones of the synapses to quantify homeostatic scaling. Related to Figure 5 in the manuscript.
    New Immunostaining Analysis Reveals Spatial and Molecular Variability in Synaptic Scaling
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    Development and Regeneration: Common Themes and Important Differences
  • Presynaptic infusion of G85R-SOD1 inhibited synaptic vesicle (SV) availability. Representative EM images illustrate morphology of AZs (labeled with red *) and numbers of SVs in fixed synapses infused with WT-SOD1 and G85R-SOD1.
    Synaptic Actions of an ALS-Associated Protein in the Giant Squid Synapse
  • The journey of cortical interneurons: (A) Cortical interneurons are born in the ganglionic eminence of the basal forebrain, and (B) migrate to reach the dorsal cortex. (C) Their number is determined upon programmed cell death and strongly depends on neuronal activity. (D) Wiring [dendritic and axonal morphogenesis and synapse establishment (1)], myelination (2) and circuit refinement of Martinotti, Basket, Chandelier and all other interneuron types is established within the first month after birth. This cartoon has been designed and drawn by Yannis Maragkos, Denaxa Lab, BSRC Al. Fleming.
    How Cortical Interneurons Develop: Current and Future Research
  • Female and male neuroscientists share ideas at a networking event.
    A Look at the Intersection of Scientific Rigor, Big Data, and Interdisciplinary Training
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    COVID-19, the Brain, and Mental Health: Weighing the Direct and Indirect Effects
    July 29, 2020 11:00 AM - 12:00 PM EDT
  • Images of graphs showing sex differences in cortical and dopaminergic neurodegeneration in 6-month-old 3K mice.
    Estrogen Benefits α-Synuclein Tetramerization and Motor Deficit in PD-Like Mice
  • Lesion histology.
    Superior Dorsolateral Prefrontal Cortex Supports Introspection in Monkeys
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    A Neurobiological Perspective on Emerging Mental Illness Research
  • Schematic representation of the molecular events following QR2 downregulation. Upon reduced QR2 expression or activity, either naturally or experimentally, there is a reduction in cellular ROS.
    QR2 Modulates Insular Cortex Redox to Enable Novel Taste Memory Formation
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