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Scientific Research

Stay apprised of findings from across the field with summaries of research published in SfN journals, and learn about rigor, responsible conduct of research, and other topics important to the scientific community.
This image shows GFAP-Cre activity (tdTomato/red) in a choroid plexus (marked by β-catenin/green) of a lateral ventricle of mouse brain at postnatal day 7.
Scientific Research
Mechanisms of Post-ischemic Brain Adaptation
August 31, 2021 11:00 AM - 12:00 PM ET
This image shows a single CA1 pyramidal cell from hippocampal area CA1 in adult rat, stained using the rapid Golgi technique. The image served as the frontispiece of Kristen Harris’ 1982 PhD thesis. It also hangs in the Boston Museum of Science.
Scientific Research
Identification of Novel Cross-Talk Between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure
August 24, 2021 12:00 PM - 1:00 PM ET
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  • Figure 1: Microbiome depletion alters how the brain responds to opioids. Microbiome intact animals in the intoxication state (left) exhibited increases in neuronal recruitment (green arrows) in the basolateral amygdala (BLA), while the central amygdala (CeA), periaqueductal gray (PAG), and locus coeruleus (LC) do not exhibit increases (blue dash) compared to control animals. During withdrawal, microbiome intact animals exhibit increased recruitment of the CeA and lateral habenula (LHB) compared to control animals. Microbiome depleted animals (right) exhibit a reduction of recruitment in the BLA, and increases in the CeA, PAG, and LC in the intoxication state compared to intact animals. Additionally, microbiome depleted animals in the withdrawal state exhibit a decrease in the CeA and an increase in recruitment in the Lateral Habenula (LHB) compared to intact animals.
    Depletion of the Microbiome Changes How the Brain Responds to Opioids
  • Scientific Image
    Meet-the-Expert: Feeling the Pressure – My Path to Sensory Neuroscience with Ellen A. Lumpkin, PhD
    August 26, 2020 11:00 AM - 12:00 PM EDT
  • Scientific Image
    Development and Regeneration Lightning Talks
  • The Betti-0 curve. A, Two-dimensional toy example: a set of 15 nodes, four filtration values ε, represented as the circle diameter and their corresponding Betti-0 (B0). B, Betti-0 curve for a hypothetical brain network; each point in the curve represents the B0 for each filtration value. In both cases, at ε = 0 the number of components is equal to the number of nodes, n. As the filtration value increases, the number of components reduces, and eventually will reach a single one containing all nodes. Brain views generated with brain-net (Xia et al., 2013), r stands for Pearson’s correlation.
    Exploring Individual Brain Connectomes With Topological Data Analysis in ADHD
  • Scientific Image
    Cortical and Hippocampal Contributions Throughout Skill Learning in Mice
  • Extracting spatial heterogeneity of AMPA receptor content within functional zones of the synapses to quantify homeostatic scaling. Related to Figure 5 in the manuscript.
    New Immunostaining Analysis Reveals Spatial and Molecular Variability in Synaptic Scaling
  • Scientific Image
    Development and Regeneration: Common Themes and Important Differences
  • Presynaptic infusion of G85R-SOD1 inhibited synaptic vesicle (SV) availability. Representative EM images illustrate morphology of AZs (labeled with red *) and numbers of SVs in fixed synapses infused with WT-SOD1 and G85R-SOD1.
    Synaptic Actions of an ALS-Associated Protein in the Giant Squid Synapse
  • The journey of cortical interneurons: (A) Cortical interneurons are born in the ganglionic eminence of the basal forebrain, and (B) migrate to reach the dorsal cortex. (C) Their number is determined upon programmed cell death and strongly depends on neuronal activity. (D) Wiring [dendritic and axonal morphogenesis and synapse establishment (1)], myelination (2) and circuit refinement of Martinotti, Basket, Chandelier and all other interneuron types is established within the first month after birth. This cartoon has been designed and drawn by Yannis Maragkos, Denaxa Lab, BSRC Al. Fleming.
    How Cortical Interneurons Develop: Current and Future Research
  • Female and male neuroscientists share ideas at a networking event.
    A Look at the Intersection of Scientific Rigor, Big Data, and Interdisciplinary Training
  • Scientific Image
    COVID-19, the Brain, and Mental Health: Weighing the Direct and Indirect Effects
    July 29, 2020 11:00 AM - 12:00 PM EDT
  • Images of graphs showing sex differences in cortical and dopaminergic neurodegeneration in 6-month-old 3K mice.
    Estrogen Benefits α-Synuclein Tetramerization and Motor Deficit in PD-Like Mice
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