Join this interactive session as Katherine Nautiyal discusses her paper, “The Serotonin 1B Receptor Modulates Striatal Activity Differentially Based on Behavioral Context”, with eNeuro Reviewing Editor Jibran Khokhar. Attendees can submit questions at registration and live during the webinar.
Below is the significance statement of the paper published Jan. 20, 2026, in eNeuro and authored by Ka H. Ng, Arati Sharma, and Katherine M. Nautiyal.
Behavioral, electrophysiological, and pharmacological evidence points to a role for serotonin modulation of striatal circuits in the brain. Our studies use in vivo calcium imaging to understand how serotonin signaling influences the dorsomedial striatum (DMS) during action and waiting behaviors. We show that serotonin signaling through the serotonin 1B receptor can have different effects on medium spiny neurons (MSNs) in the DMS depending on the ongoing behavior—increasing MSN activity during rewards and decreasing MSN activity during inhibition. These data show that serotonin effects on striatal circuitry are complex and can be dependent on behavioral context.
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