Neuronal Aging: A Major Risk for Cognitive Decline in Humans
Dec 22, 2025
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- Presidential Special Lectures
This Presidential Special Lecture was recorded Nov. 18, 2025, at Neuroscience 2025 in San Diego.
This lecture will address the question: Why do we lose cognitive capacity and function as we age? New cellular models of human brain aging have led to a more comprehensive understanding of the cellular and molecular mechanisms that underly brain aging. Energy metabolism, inflammation, and genome instability combine to drive cognitive decline in age and disease.
About the Contributor
Dr. Gage is a Professor in the Laboratory of Genetics at The Salk Institute for Biological Studies and an Adjunct Professor in the Department of Neurosciences at the University of California, San Diego. Dr. Gage’s laboratory currently studies neurogenesis, modeling of various neurodegenerative and neuropsychiatric disorders, neuronal mosaicism and diversity, human evolution, and somatic retrotransposition. He received both his MS and PhD from Johns Hopkins University, where he also served as an NIMH Predoctoral Fellow. In 2024, Dr. Gage was recognized as the recipient of the J. Allyn Taylor International Prize in Medicine and the Ogawa-Yamanaka Stem Cell Prize.
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