The Importance of Synapses in Alzheimer's Disease
Dec 22, 2025
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- Presidential Special Lectures
This Presidential Special Lecture was recorded Nov. 16, 2025 at Neuroscience 2025 in San Diego.
Alzheimer’s disease is one of the most pressing medical issues of our time. In this lecture, Spires-Jones discusses advances in understanding the role of synapses in disease pathogenesis, including the accumulation of pathological proteins within synapses, the involvement of glia in synapse degeneration, and trans-synaptic spread of pathology through the brain. The lecture will explore the importance of understanding synaptic pathology for developing life-changing treatments.
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