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Building Things in Brains: Chemistry Construction Projects for Analysis and Discovery in Neural Systems
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  • This mirrored image shows a CA1 neuron before (left side) and after (right side) activation of excitotoxicity by metabotropic NMDA receptors and pannexin-1, a postsynaptic ion and metabolite channel. Metabotropic NMDAR signaling regulates pannexin-1 through Src kinase. This pathway suppresses facilitated release of presynaptic glutamate during synaptic activity by regulating tissue levels of the TRPV1 agonist anandamide.
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  • This image shows a single CA1 pyramidal cell from hippocampal area CA1 in adult rat, stained using the rapid Golgi technique. The image served as the frontispiece of Kristen Harris’ 1982 PhD thesis. It also hangs in the Boston Museum of Science.
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  • Scientific image courtesy of Julie Marocha, from https://www.jneurosci.org/content/38/11.cover-expansion.
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