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Input-Independent Homeostasis of Developing Thalamocortical Activity
June 22, 2021 12:00 PM - 1:00 PM
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  • Marguerite Matthews talking during a roundtable session at Neuroscience 2019 in Chicago, IL
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    Black Lives Matter and Neuroscience: Maintaining the Movement
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  • This image shows corticofugal axons (green) projecting from layer 5 of the mouse primary visual cortex to the dorsal striatum. Layer 5 projections from primary visual, primary somatosensory, primary motor, and ventromedial orbitofrontal cortex all have terminal fields within the striatum, among other common targets. Blue is DAPi nuclear stain.
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  • This image shows a single CA1 pyramidal cell from hippocampal area CA1 in adult rat, stained using the rapid Golgi technique. The image served as the frontispiece of Kristen Harris’ 1982 PhD thesis. It also hangs in the Boston Museum of Science.
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    Input-Independent Homeostasis of Developing Thalamocortical Activity
    June 22, 2021 12:00 PM - 1:00 PM ET
  • This picture shows Purkinje cells (green), proliferating cells (cyan), and cell nuclei (purple) in a postnatal day 7 mouse cerebellum. The p75 neurotrophin receptor promotes cell-cycle exit by proliferating cerebellar granule cell precursors. Loss of this receptor prolongs granule cell precursor proliferation, resulting in increased glutamatergic input to Purkinje cells and deficits cerebellum dependent learning.
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  • This image shows a retinal section from a mouse in which a subset of amacrine cells was labeled with an antibody against the transcription factor Meis 2 (green), which was identified in a single-cell RNA sequencing expression screen that characterized >60 amacrine cell types. The section was also stained to mark two classes of inhibitory neurons, GABAergic (magenta) and glycinergic (cyan).
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    Cultivating Inclusivity: Leading Your Training Environment
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  • This mirrored image shows a CA1 neuron before (left side) and after (right side) activation of excitotoxicity by metabotropic NMDA receptors and pannexin-1, a postsynaptic ion and metabolite channel. Metabotropic NMDAR signaling regulates pannexin-1 through Src kinase. This pathway suppresses facilitated release of presynaptic glutamate during synaptic activity by regulating tissue levels of the TRPV1 agonist anandamide.
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    Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration
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  • This image shows GFAP-Cre activity (tdTomato/red) in a choroid plexus (marked by β-catenin/green) of a lateral ventricle of mouse brain at postnatal day 7.
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    Brain Stroke
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