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  • Striatal neurons from embryonic day 17.5 Frizzled3 knock-out mice, stained for dopamineand cAMP-regulated phosphoprotein of 32 kDa (DARPP-32; green). The striatum is normally heavily innervated by meso-diencephalic axons at this developmental stage, but the neurons shown here still await innervation by these projections.
    Pío del Río Hortega: Notes from His Grandnephew
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    Psychiatric Disorders and Microglia
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    Microglia in Neurodegeneration
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    Models in Microglial Research
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    Tools to Study Microglia
  • This image shows ventral striatal neurons from a rodent brain. The cell bodies are stained in blue using a fluorescent NISSL stain (NeuroTrace). A light sensitive virus for optogenetics was transducted into neurons shown in yellow. Neurons in this area are involved in scaling fear to the degree of threat and in rapid discrimination of uncertain threat and safety.
    Calcium Imaging Journal Articles
  • This mirrored image shows a CA1 neuron before (left side) and after (right side) activation of excitotoxicity by metabotropic NMDA receptors and pannexin-1, a postsynaptic ion and metabolite channel. Metabotropic NMDAR signaling regulates pannexin-1 through Src kinase. This pathway suppresses facilitated release of presynaptic glutamate during synaptic activity by regulating tissue levels of the TRPV1 agonist anandamide.
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    Fos Activation Journal Articles
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    Optogenetics Journal Articles
  • This confocal image shows a fluorescently labeled mouse vomeronasal organ at embryonic day 13.5. The developing vomeronasal organ is composed of two distinct neuronal types that can be distinguished based on the expression of the specific transcription factors AP-2ε(cyan) and Meis2 (magenta).
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  • Voltage-sensitive Dye Imaging and Chemogenetics Journal Articles
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