This an audio-only recording captured at Neuroscience 2018.
In this Meet the Expert, Chenghua Gu discusses new tools and methods her lab is using to study the blood brain barrier in vivo — particularly the relationship between neurons and endothelial cells.
The blood brain barrier functions as the gatekeeper of the CNS and the barrier that prevents most drugs from passing from the bloodstream into the CNS. The Gu Lab seeks to investigate the fundamental cellular and molecular mechanisms that govern the formation and regulation of the blood brain barrier, as well as how neural and vascular systems work together to ensure proper brain function.
Increased understanding of the mechanisms and functional aspects of neurovascular interactions has potential to enable bidirectional manipulation of the blood brain barrier.