Join this interactive session as Julie-Anne Balouek and Catherine Jensen Peña discuss their paper, “Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivity”, with JNeurosci Reviewing Editor, Mary Kay Lobo. Attendees can submit questions at registration and live during the webinar.
Below is the significance statement of the paper published on July 10, 2023 in JNeurosci and authored by Julie-Anne Balouek, Christabel A. Mclain, Adelaide R. Minerva, Rebekah L. Rashford, Shannon N. Bennett, Forrest D. Rogers and Catherine Jensen Peña.
Early-life stress enhances sensitivity to stress later in life, yet the mechanisms of such stress sensitization are largely unknown. Here, we show that neuronal ensembles in corticolimbic brain regions remain hypersensitive to stress across the lifespan, and quieting these ensembles during experience of adult stress rescues stress hypersensitivity.
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