Scientific Research

Synaptic Mechanisms Underlying Temporally Precise Information Processing in the VNLL, an Auditory Brainstem Nucleus

September 27, 2022

12:00 PM - 1:00 PM ET

Join this interactive session as Dr. Felix Felmy and Dr. Nikolaos Kladisios discuss their paper, “Synaptic Mechanisms underlying Temporally Precise Information Processing in the VNLL, an auditory brainstem nucleus”, with JNeurosci Reviewing Editor Ruth Anne Eatock. Attendees can submit questions at registration and live during the webinar.

Below is the significance statement of the paper published on June 22, 2022, in JNeurosci and authored by Nikolaos Kladisios, Linda Fischer, Florian Jenzen, Michael Rebhan, Christian Leibold, and Felix Felmy

Auditory information processing in the brainstem is a prerequisite for generating our auditory representation of the environment. Thereby, many processing steps rely on temporally precise filtering. Precise feed forward inhibition is a key motif in auditory brainstem processing and produced through sign inversion at several large somatic excitatory synapses. A particular feature of the ventral nucleus of the lateral lemniscus is to produce temporally precise onset inhibition with little temporal variance independent of sound intensity. Our cell-physiology and modeling data explain how the synaptic characteristics of different current components and their short-term plasticity are tuned to establish sound intensity-invariant onset inhibition that is crucial for filtering out spurious frequency information.

Speakers

Felix Felmy, PhD

Felix Felmy is a professor at the Institute of Zoology at the University for Veterinary Medicine Hannover. He previously was a junior group leader at the Institute for Neurobiology at the Ludwig-Maximilian-University Munich. Felmy’s main research interests lie in biophysical description of functionally relevant input-output functions in the auditory brainstem pathways. He received his undergraduate degree in Biology from Eberhard-Karls University of Tübingen and his PhD in synaptic physiology conducted at the Max-Plank Institute for biophysical Chemistry from Eberhard-Karls University of Tübingen. He completed his postdoctoral training at The Vollum Institute in Portland.

Nikolaos Kladisios, PhD

Nikolaos Kladisios is a Postdoc at the Institute of Zoology at the University of Veterinary Medicine Hannover. Kladisios’s main research interests include in vitro and in vivo characterization of biophysical properties of auditory brainstem nuclei. He earned his B.S. in Biology from the Leibniz University Hannover and his PhD from the University of Veterinary Medicine Hannover, where he continues with his postdoctoral training.

Ruth Anne Eatock, PhD

Ruth Anne Eatock is a professor of neurobiology in the neuroscience department at the University of Chicago. Eatock’s lab studies the mechanosensory signaling in the inner ear, focusing on the mouse utricle. She earned her BSc in honors neurobiology and MSc in biology from McGill University, her PhD in biology from Caltech, and completed postdoctoral training at MIT.

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Synaptic Mechanisms Underlying Temporally Precise Information Processing in the VNLL, an Auditory Brainstem Nucleus

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