Material below summarizes the article Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and Plasticity, published on September 25, 2019, in eNeuro and authored by Emily Hill, Thomas K. Karikari, Kevin G. Moffat, Magnus J. E. Richardson, and Mark J. Wall.
Highlights
- Introduction of nanomolar concentrations of tau oligomers into cortical neurons causes significant changes in action potential kinetics in a 40-minute timeframe.
- Introduction of tau oligomers into the presynaptic cell of synaptically connected pairs impairs basal synaptic transmission and enhances short-term depression.
- Introduction of tau oligomers into the postsynaptic cell of synaptically connected pairs has no effect on basal synaptic transmission but markedly impairs synaptic plasticity (long-term potentiation).
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About the Contributors
Emily Hill Emily Hill is a neuroscience PhD student at the University of Warwick, in the United Kingdom.
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