Join this interactive session as Matthew Colonnese discusses his recent eNeuro paper, “Input-Independent Homeostasis of Developing Thalamocortical Activity.” After the talk, eNeuro Editor-in-Chief Christophe Bernard will moderate the discussion and take questions from the audience. You can submit questions through registration and will have the opportunity to pose questions during the webinar through a Q&A box.
Below is the significance statement of Input-Independent Homeostasis of Developing Thalamocortical Activity, published on May 4, 2021, in eNeuro and authored by Pouria Riyahi, Marnie A Phillips, and Matthew T Colonnese.
Uncovering the mechanistic underpinnings of EEG development is critical to increasing the diagnostic potential of this cheap and portable methodology. An important component of this maturation is the acquisition of activity that is continuous, i.e. lacking silent periods. Here we used background activity in the visual cortex of developing unanesthetized mice to show that the primary sensory input plays little role in the development of continuity and normal firing rates, which instead appear to be regulated by mechanism internal to thalamus and cortex. These findings suggest that damage to driving thalamic inputs will be difficult to detect by EEG, and point to the importance of firing rate homeostasis in regulating even early development.