Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration
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Join this interactive session as Paula Salamone and Agustín Ibañez discuss their recent JNeurosci paper, “Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration.” After the talk, JNeurosci Editor-in-Chief Marina Picciotto will moderate a conversation. You can submit questions through the registration and will have the opportunity to pose questions during the webinar through a Q&A box.
Below is the significance statement of Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration, published on April 7, 2021, in JNeurosci and authored by Paula C. Salamone, Agustina Legaz, Lucas Sedeño, Sebastián Moguilner, Matías Fraile-Vazquez, Cecilia Gonzalez Campo, Sol Fittipaldi, Adrián Yoris, Magdalena Miranda, Agustina Birba, Agostina Galiani, Sofía Abrevaya, Alejandra Neely, Miguel Martorell Caro, Florencia Alifano, Roque Villagra, Florencia Anunziata, Maira Okada de Oliveira, Ricardo M. Pautassi, Andrea Slachevsky, Cecilia Serrano, Adolfo M. García, and Agustín Ibañez.
Salamone, Legaz, et al. examined whether and how emotions are primed by interoceptive states combining multimodal measures in healthy controls and neurodegenerative models. In controls, negative emotion recognition and ongoing heart-evoked potential modulations were increased after interoception. These patterns were selectively disrupted in patients with atrophy across key interoceptive-emotional regions (e.g., the insula and the cingulate in frontotemporal dementia, frontostriatal networks in Parkinson’s disease), whereas persons with Alzheimer’s disease presented generalized emotional processing abnormalities with preserved interoceptive mechanisms. The integration of both domains was associated to the volume and connectivity (salience network) of canonical interoceptive-emotional hubs, critically involving the insula and the anterior cingulate. This study reveals multimodal markers of interoceptive-emotional priming, laying the groundwork for new agendas in cognitive neuroscience and behavioral neurology.
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