Join this interactive session as Khalid Elsaafien and Eric Krause discuss their paper, “Identification of Novel Cross-Talk between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure” with JNeurosci Editor-in-Chief Marina Picciotto. Attendees can submit questions at registration and live during the webinar.
Below is the significance statement of Identification of Novel Cross-Talk between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure, published on May 26, 2021, in JNeurosci and authored by Khalid Elsaafien, Matthew K. Kirchner, Mazher Mohammed, Sophia A. Eikenberry, Chloe West, Karen A. Scott, Annette D. de Kloet, Javier E. Stern, and Eric G. Krause.
The survival of an organism is dependent on meeting the energetic demands imposed by stressors. This critical function is accomplished by the CNS's ability to orchestrate simultaneous activities of neurosecretory and autonomic axes. Here, we unveil a novel signaling mechanism within the paraventricular nucleus of the hypothalamus that links excitation of neurons producing corticotropin-releasing-hormone with excitation of neurons controlling sympathetic nervous system activity and blood pressure. The implication is that chronic stress exposure may promote cardiometabolic disease by dysregulating the interneuronal cross-talk revealed by our experiments.
Marina Picciotto, PhD
Marina Picciotto is Charles B. G. Murphy Professor of psychiatry, a professor in the child study center of neuroscience and pharmacology, the director of molecular psychiatry, the deputy chair for basic science research in the department of psychiatry, the deputy director of the Kavli Institute for Neuroscience, and the co-director of the neuroscience research training program in the psychiatry department at Yale University. Picciotto is the editor-in-chief of The Journal of Neuroscience. She previously served on the scientific council of the National Institute on Drug Abuse, as the Treasurer of SfN, and President of the Society for Research on Nicotine and Tobacco. Her research interests lie in the role of nicotinic acetylcholine receptors in mouse models, including research related to addiction, depression, brain development, learning, and appetite. She earned her BS in biology from Stanford University, PhD in molecular neurobiology from Rockefeller University, and completed her postdoctoral training at the Pasteur Institute.
Eric G. Krause, PhD
Eric G. Krause, Ph.D. is a tenured associate professor in the department of pharmacodynamics, College of Pharmacy at the University of Florida. Krause also holds University of Florida Term and Research Foundation Professorships and serves as the Director of the Center for Integrative Cardiovascular and Metabolic Disease. His primary area of research investigates specific connections within the brain that promote susceptibility or resiliency to stress-related diseases like mental health and cardiovascular disorders. Krause received a and PhD in neuroscience from Florida State University. Subsequently, he completed postdoctoral training in the department of psychiatry and behavioral neuroscience at the University of Cincinnati.
Khalid Elsaafien, PhD
Khalid Elsaafien is a postdoctoral fellow in the department of pharmacodynamics, College of Pharmacy at the University of Florida. Elsaafien’s research focuses on understanding the interplay between the autonomic nervous system and the cardiovascular system. He earned his BS in neuroscience from the University of Melbourne, and his PhD in neuroscience from the Florey Institute of Neuroscience and Mental Health at the University of Melbourne, Australia.