Material below summarizes the article Dominant Neuropeptide Cotransmission in Kisspeptin-GABA Regulation of GnRH Neuron Firing Driving Ovulation, published on July 11, 2018, in JNeurosci and authored by Richard Piet, Bruna Kalil, Tim McLennan, Robert Porteous, Katja Czieselsky, and Allan E. Herbison.
Fertility in all mammals is governed by a small population of neurons scattered in the basal forebrain that secrete gonadotropin-releasing hormone (GnRH).
GnRH neurons project to the median eminence and release GnRH into the pituitary portal blood system. In the anterior pituitary, GnRH stimulates secretion into the blood of the gonadotropins follicle-stimulating hormone and luteinizing hormone (LH), which in turn act in the gonads to promote gametogenesis and sex steroid hormone production.
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