Human Brain Disorders in a Dish: Induced Pluripotent Stem Cell Models of Disease

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Ricardo Dolmetsch, PhD
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Lisa Ellerby, the Neurobiology of Huntington's Disease
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Flora Vaccarino, Building a Cortex in a Dish
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You Asked, They Answered: Induced Pluripotent Stem Cell Models of Disease
You Asked They Answered: Induced Pluripotent Stem Cell Models of Disease (33:33)

There has been an explosion of interest in using induced pluripotent stem cells (iPSCs) to model human disease and human development. The excitement over the obvious benefits may need to be tempered with caution concerning unanswered questions about the validity of various disease models as well as concerns over technical issues. With this burst of new information comes an opportunity to take stock of the landscape and integrate the findings into an updated, modern view of human disease exploration. 

The aim of the 2013 Neurobiology of Disease workshop at the Society for Neuroscience’s annual meeting was to help frame important unanswered research questions related to iPSC-based disease modeling, and to stimulate the interest and understanding of investigators new to the field.  

The Neurobiology of Disease Workshop provides students and early-career scientists with in-depth overviews of diseases of the nervous system.

Speakers:

 Jon-Bernstein, PhD

Jon Bernstein, MD, PhD

Jon Bernstein is the director of the Stanford Medical Genetics Residency Program and is an assistant professor of pediatrics (genetics) at Lucile Salter Packard Children’s Hospital. His interests include the genetics of autism and other developmental disorders. In collaboration with colleagues at Stanford, he is working to develop induced pluripotent stem cell models of genetic disorders associated with developmental disability. He is also engaged in the application of new technologies (whole genome sequencing, multi-omics profiling) for the diagnosis of developmental disorders.

Ricardo-Dolmetsch, PhD

Ricardo Dolmetsch, PhD

Ricardo Dolmetsch is the global head of neuroscience at the Novartis Institutes for BioMedical Research. His group is responsible for leveraging advances in human genetics to model and treat neuropsychiatric and neurodegenerative diseases. Areas of focus include genomics, induced pluripotent stem cells, and brain circuitry.

 Kristen Brennand, PhD

Kristen Brennand, PhD

Kristen Brennand is an assistant professor of psychiatry and neuroscience at the Icahn School of Medicine at Mount Sinai. A stem cell biologist, she is focused on developing in vitro models for schizophrenia in order to identify novel insights into the molecular and cellular phenotypes of mental illness.

Lorenz Studer, MD

Lorenz Studer, MD, PhD

Lorenz Studer is the director of the Sloan-Kettering Center for Stem Cell Biology, a member of the developmental biology program at the Sloan-Kettering Institute, and a professor in neuroscience at Weill-Cornell Medical School. His laboratory increasingly focuses on the translational application of human pluripotent stem cells in disease modeling, drug discovery, and cell therapy. He currently leads a multidisciplinary consortium to pursue the first clinical application of human embryonic stem cell derived dopamine neurons for the treatment of Parkinson's disease.

Ole-Isacson, PhD

Ole Isacson, MD, PhD

Ole Isacson is a professor of neurology and neuroscience at Harvard Medical School and founding director of the Neuroregeneration Research Institute/Neuroregeneration Laboratories at McLean Hospital. He is the principal investigator and chair of NIH’s National Institute of Neurological Disorders and Stroke Parkinson’s Disease iPS Cell Research Consortium. Isacson’s research aims to provide novel technology and biological insights beyond currently available drug therapies for Parkinson’s disease. Isacson is editor-in-chief of Molecular and Cellular Neuroscience and a member of several editorial boards. He is also a member of The Michael J. Fox Foundation’s Scientific Advisory Board.

Lisa-Ellerby, PhD

Lisa Ellerby, PhD

Lisa Ellerby is an associate professor at the Buck Institute for Research on Aging. She is an expert on cell death in neurodegenerative disorders such as Huntington's disease. Ellerby and her Buck colleague Robert Hughes recently discovered a new lead to potential drug therapies for Huntington's disease by focusing on the huntingtin protein (Htt). In 2010, Ellerby was one of the lead authors of a Neuron cover article about this research. The Ellerby lab is also exploring possible methods to stimulate the growth of new nerve cells to replace those lost in Huntington’s disease sufferers.

Flora Vaccarino, MD

Flora Vaccarino, MD, PhD

Flora Vaccarino is a professor at Yale University School of Medicine. Her lab studies mouse and human neural stem cells and their role in development and repair. She and a group of colleagues recently founded the Program in Neurodevelopment and Regeneration to harness the power of induced pluripotent stem cells for understanding individual variation in neurodevelopment and the pathophysiology of neuropsychiatric disorders.

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