Material below summarizes the article 3D Electron Microscopy Study of Synaptic Organization of the Normal Human Transentorhinal Cortex and Its Possible Alterations in Alzheimer’s Disease, published on June 19, 2019, in eNeuro and authored by M. Domínguez-Álvaro, M. Montero-Crespo, L. Blazquez-Llorca, J. DeFelipe, and L. Alonso-Nanclares.
Highlights
- The majority of synapses are excitatory on spine heads (55%) and have a small disk shape. Nevertheless, a relatively large proportion of excitatory synapses are established on dendritic shafts (37%).
- Excitatory and inhibitory synapses show different preferences for their postsynaptic targets (spines or dendritic shafts).
- In Alzheimer’s disease (AD), morphological synaptic changes and a reduction in the number of synapses targeting spine heads occur.
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About the Contributors
Domínguez-Álvaro is a graduate student at the Polytechnic University of Madrid, in Spain, where she works in the Cajal Laboratory of Cortical Circuits in the Center for Biomedical Technology.
Alonso-Nanclares is an assistant researcher in the Cajal Laboratory of Cortical Circuits in the Center for Biomedical Technology, at the Polytechnic University of Madrid, in Spain, and the Cajal Institute (CSIC).
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