Material below summarizes the article Orchestration of Neuronal Differentiation and Progenitor Pool Expansion in the Developing Cortex by SoxC Genes, published on July 22, 2015, in JNeurosci and authored by Chao Chen, Garrett A. Lee, Ariel Pourmorady, Elisabeth Sock, and Maria J. Donoghue.
As the brain forms, there is a dynamic tension between whether a cell divides to make more mitotically active cells or differentiates to become neuron or glia. In the cerebral cortex, the biggest and most complex part of the mammalian brain, dividing cells reside close to the lateral ventricle and differentiated cells occupy domains closer to the skull.
Historically, the scientific community treated dividing cells as a single population; however, recent studies have demonstrated that there is a second population of dividing cells located a distance away from the ventricle, in the subventricular zone, that are called intermediate progenitor cells (IPCs).
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