Join this interactive session as Dr. Leila Reddy discusses her paper, “Human Hippocampal Neurons Track Moments in a Sequence of Events” with JNeurosci Editor-in-Chief Marina Picciotto. Attendees can submit questions at registration and live during the webinar.
Below is the significance statement of the paper published on August 4, 2021, in JNeurosci and authored by Leila Reddy, Benedikt Zoefel, Jessy K. Possel, Judith Peters, Doris E. Dijksterhuis, Marlene Poncet, Elisabeth C. W. van Straaten, Johannes C. Baayen, Sander Idema, and Matthew W. Self.
Episodic memory refers to our ability to remember the what, where, and when of a past experience. Representing time is an important component of this form of memory. Here, we show that neurons in the human hippocampus represent temporal information. This temporal signature was observed both when participants were actively engaged in a memory task, as well as during 10-s-long gaps when they were asked to wait before performing the task. Furthermore, the activity of the population of hippocampal cells allowed for decoding one temporal epoch from another. These results suggest a robust representation of time in the human hippocampus.