Stem cell-derived motor neurons provide a unique opportunity to study molecular processes controlling specification of neuronal identity and to probe pathological processes leading to neurodegeneration in patients with amyotrophic lateral sclerosis.
Hynek Wichterle, whose lab models and studies the development of the nervous system in vitro, will cover:
- What it means to become a defined neuronal cell type in the central nervous system.
- Findings that neuronal genes are controlled by distributed enhancers rather than super-enhancers.
- Approaches to modeling neurodegenerative diseases including amyotrophic lateral sclerosis, a degenerative disease of spinal motor neurons.
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