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In this interactive session, Candler Paige and Ted Price will discuss their paper, “A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models” with JNeurosci editor-in-chief Marina Picciotto. Attendees can submit questions at registration and during the live webinar.
Below is the significance statement of the paper published March 9, 2022, in JNeurosci and authored by Candler Paige, Isabel Plasencia-Fernandez, Moeno Kume, Melina Papalampropoulou-Tsiridou, Louis-Etienne Lorenzo, Eric T. David, Lucy He, Galo L. Mejia, Christopher Driskill, Francesco Ferrini, Andrew L. Feldhaus, Leon F. Garcia-Martinez, Armen N. Akopian, Yves De Koninck, Gregory Dussor, and Theodore J. Price:
The majority of patients impacted by chronic pain are women. Mechanistic studies in rodents are creating a clear picture that molecular events promoting chronic pain are different in male and female animals. We sought to build on evidence showing that CGRP is a more potent and efficacious promoter of headache in female than in male rodents. To test this, we used hyperalgesic priming and the spared nerve injury neuropathic pain models in mice. Our findings show a clear sex dimorphism wherein CGRP promotes pain in female but not male mice, likely via a centrally mediated mechanism of action. Our work suggests that CGRP receptor antagonists could be tested for efficacy in women for a broader variety of pain conditions.
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