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Arthur William English, PhD

Arthur William English is a professor in the department of cell biology with a joint appointment in rehabilitation medicine at the University of Illinois, where he also obtained his PhD. During more than 45 years as a professor, English has made contributions in various aspects of motor physiology. For the last 15 years his research has focused on the effects of activity, neurotrophins, and exercise in motor and sensory axon regeneration after nerve injury.

By This Contributor

  • This image shoes the relative KCC2 depletion in WT and CX3CR1 BDNF KO animals 14 d after cut/ligation. Genotype had no effect on KCC2 levels in motoneurons contralateral or ipsilateral to injury. Removing BDNF from microglia had no impact on KCC2 expression. Lumbar spinal cord sections from animals expressing normal CSF1 and with CSF1 removed from motoneurons 14 d after ligation. ChatIREScre/+: : csf1f/f animals exhibit normal microgliosis in the dorsal horn but have the microglial reaction to injury greatly attenuated in the ventral horn compared to ChatI+/+: : csf1f/f. KCC2 immunofluorescence 14 d after sciatic ligation in csf1f/f animals. Preventing microgliosis in the ventral horn had no impact on KCC2 within intact or injured motoneurons. Error bars = SEM; **p ≤ 0.01, ***p ≤ 0.001.
    KCC2 on Axotomized Motoneurons Is Regulated Differently Than in Systems Previously Described
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