Learn how to simulate strokes with the simulation platform, The Virtual Brain. We will go through two papers: Functional Mechanisms of Recovery after Stroke: Modeling with The Virtual Brain and The Virtual Brain: Modeling Biological Correlates of Recovery After Chronic Stroke, and apply the same processes with our own structural connectivity data set in The Virtual Brain.

Topics covered in this lesson:

• Overview of modelling strokes in The Virtual Brain
• Parameter settings for modelling strokes in The Virtual Brain
• Visualizing results of simulations in The Virtual Brain
• Parameter space exploration

External links:

• Publication
• The Virtual Brain

Learn how to simulate seizure events and epilepsy in The Virtual Brain. We will look at the paper: On the Nature of Seizure Dynamics which describes a new local model called the Epileptor, and apply this same model in The Virtual Brain. This is part 1 of 2 in a series explaining how to use the Epileptor. In this part, we focus on setting up the parameters.

Topics covered in this lesson:

• Overview of modelling seizure in The Virtual Brain
• Overview of The Epileptor
• Overview of the 5 differential equations of The Epileptor
• Configuring parameters for modelling seizure in The Virtual Brain

External links:

• Publication
• The Virtual Brain

In this lecture we will focus on a paper called “The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread”. Within their work, the authors used the epileptor model to simulate a patient's individual seizure. To understand the concept we will have a closer look at the equations of the epileptor model and particular the epileptogenicity index which controls the excitability of each brain region. Subsequently, we will begin to setup the epileptogenic zone in our own brain network model with TVB.

Topics covered in this lesson:

• Local epileptor model and epileptogenic zone
• Setting up a brain network for epilepsy

External links:

• Publication
• The Virtual Brain

After introducing the local epileptor model in the previous 2 videos we will now use it in a large scale brain simulation. We again focus on the paper “The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread”. Two simulations with different epileptogenicity across the network are visualized to show the difference in seizure spread across the cortex.

Topics covered in this lesson:

• Running epileptic seizure simulations in TVB

External links:

• Publication
• The Virtual Brain

This lecture gives an overview on the article “Individual brain structure and modelling predict seizure propagation” where 15 subjects with epilepsy were modelled to predict individual epileptogenic zones. With the TVB GUI we will model seizure spread and the effect of lesioning the connectome. The impact of cutting edges in the network on seizure spreading will be visualized.

Topics covered in this lesson:

• Individual epilepsy modelling
• Impact of connectome manipulation on seizure spread

External links:

• Publication
• The Virtual Brain