Understanding Sonic Hedgehog Signaling Pathway in Hippocampal Neurons
Material below summarizes the article Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation, published on December 9, 2015, in JNeurosci and authored by Pamela J. Yao, Ronald S. Petralia, Carolyn Ott, Ya-Xian Wang, Jennifer Lippincott-Schwartz, and Mark P. Mattson.
The development and maintenance of neural circuits in the brain are controlled by diverse signaling pathways. Recent research has revealed the role of Sonic Hedgehog (Shh), a secreted protein signaling in regulating neural networks in some areas of the brain. In the case of the hippocampus, we have known the existence of the key signaling components of the Shh pathway. However, the function of the Shh signaling pathway in the hippocampus, particularly in the hippocampal neuron, has remained mostly unknown.
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