Material below is adapted from the SfN Short Course TREM2 Variants: New Keys to Decipher Alzheimer’s Disease Pathogenesis, by Marco Colonna, MD, and Yaming Wang, PhD. Short Courses are day-long scientific trainings on emerging neuroscience topics and research techniques held the day before SfN’s annual meeting.
Mutations in the gene that encodes triggering receptor expressed on myeloid cells 2 (TREM2) were originally discovered in patients with a very rare form of inheritable dementia. TREM2 is a transmembrane protein expressed on the surface of microglia, the cells that function as macrophages in the central nervous system (CNS).
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