Transcriptional Regulation of an Endoplasmic Reticulum Calcium Sensor
Material below summarizes the article NEUROD2 Regulates Stim1 Expression and Store-Operated Calcium Entry in Cortical Neurons, published on February 27, 2017, in eNeuro and authored by Gokhan Guner, Gizem Guzelsoy, Fatma Sadife Isleyen, Gulcan Semra Sahin, Cansu Akkaya, Efil Bayam, Eser Ilgin Kotan, Alkan Kabakcioglu, and Gulayse Ince-Dunn.
The cerebral cortex is the seat of higher cognitive functions such as learning, memory, planning, language acquisition, attention, and consciousness. In order to carry out these complex tasks, the cortex is composed of myriad types of neurons amounting to approximately 20-25 billion in humans.
A large proportion of these neurons — excitatory neurons — use the excitatory neurotransmitter glutamate and assemble into circuits that function in local communications and long-distance communications with other parts of the brain. A formidable task for the developing cerebral cortex is the production, differentiation, and assembly of excitatory cortical neurons into properly functioning networks.
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