Material below summarizes the article MAP1B Light Chain Modulates Synaptic Transmission via AMPA Receptor Intracellular Trapping, published on September 13, 2017, in JNeurosci and authored by Rocío Palenzuela, Yolanda Gutiérrez, Jonathan E. Draffin, Argentina Lario, Marion Benoist, and José A. Esteban.
The regulation of neuronal communication in the brain is crucial for all our cognitive functions.
Traditionally, this has been thought to occur at the level of synaptic connections, where the neurotransmitter signal released from one neuron is received by the adjacent neuron via neurotransmitter receptors.
It is now well established that neurons can modify the number of neurotransmitter receptors present at the synapse. This process, a form of synaptic plasticity, is one basis for learning and memory.
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