Synaptic Actions of an ALS-Associated Protein in the Giant Squid Synapse
Jul 16, 2020
Material below summarizes the article Synaptic Actions of Amyotrophic Lateral Sclerosis-Associated G85R-SOD1 in the Squid Giant Synapse. published on March 18, 2020, in eNeuro and authored by Yuyu Song.
Highlights
- ALS-associated G85R-SOD1 inhibits synaptic transmission in the squid giant synapse.
- ALS-associated G85R-SOD1 increases Ca2+ concentration at the presynaptic terminal including the “Palm” region, which lacks Ca2+ channels, suggesting potential Ca2+ reservoir in the presynaptic compartment.
- Surprisingly, intermittent High Frequency Stimulation (iHFS), which normally depletes synaptic vesicles and causes synaptic depression, rescued synaptic function affected by G85R-SOD1 when applied every 30 minutes before and during G85R-SOD1 protein infusion.
Access to the full article is available to SfN members.
Neuronline is a benefit of SfN membership. Renew your membership now to make sure you don’t lose access.
About the Contributor
Yuyu Song is junior faculty at Massachusetts General Hospital and Harvard Medical School. Her research interests focus on the molecular basis of pathogenesis for neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s disease (AD).
0 of 5 articles left
Login
or
Become a Member
to unlock content
