Material below summarizes the article Phosphoinositol-4,5-bisphosphate Regulates Auditory Hair Cell Mechanotransduction Channel Pore Properties and Fast Adaptation, published on October 24, 2017, in JNeurosci and authored by Thomas Effertz, Lars Becker, Anthony W. Peng, and Anthony J. Ricci.
In vertebrates, sound is detected by the organ of Corti, a sensory epithelium located inside the cochlea, the snail shell shaped part of our inner ear. The organ of Corti comprises one row of inner hair cells (IHC), which function as microphones, and three rows of outer hair cells (OHC), which function as amplifiers of faint sound stimuli.
Both IHCs and OHCs possess a sensory organelle, termed hair bundle, on their apical surface that consists of multiple rows of actin-filled stereocilia. The stereocilia are arranged in a staircase pattern, with each shorter stereocilium connected to its taller neighbor at the tips through filaments, termed tip links.
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