Obesity and APOE4: Gene-Environment Interaction in Alzheimer’s Disease
Material below summarizes the article Obesity Accelerates Alzheimer-Related Pathology in APOE4 but Not APOE3 Mice, published on June 12, 2017, in eNeuro and authored by V. Alexandra Moser, and Christian J. Pike.
Alzheimer’s disease (AD) is a complex, multi-factorial disease for which a number of genetic, environmental, and lifestyle risk factors have been identified.
For the vast majority of those afflicted, AD does not result from any single factor, but rather the interactive effects of multiple risk factors. Despite the importance of interactions among risk factors, our understanding of how the combination of these variables affects development and progression of AD is poorly understood.
In this paper, we investigated the gene-environment interaction between two well-established AD risk factors, apolipoprotein E4 (APOE4) and obesity.
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