Novel Viral-Genetic Method for Tracing Axon Collaterals of Broadly Projecting Neurons
Oct 22, 2020
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Material below summarizes the article An Intersectional Viral-Genetic Method for Fluorescent Tracing of Axon Collaterals Reveals Details of Noradrenergic Locus Coeruleus Structure, published on April 30, 2020, in eNeuro and authored by Nicholas W. Plummer, Daniel J. Chandler, Jeanne M. Powell, Erica L. Scappini, Barry D. Waterhouse and Patricia Jensen.
Highlights
- TrAC (Tracing Axon Collaterals) is a new viral-genetic method that allows simultaneous visualization of axon collaterals from a genetically defined neuronal population and a projection-based subpopulation.
- TrAC was used to show that norepinephrine (NE)-containing locus coeruleus (LC) neurons projecting to the medial prefrontal cortex and primary motor cortex differ from each other and from the LC as a whole in their pattern of axon collateralization.
- Labeled LC-NE neurons have dense axon projections to their primary target in the cerebral cortex, and widespread, albeit sparse, collateral projections to other cortical and subcortical regions.
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About the Contributors
Nicholas Plummer is a staff scientist in the Developmental Neurobiology Group at the National Institute of Environmental Health Sciences.
Daniel Chandler is an assistant professor in the department of cell biology and neuroscience at Rowan University School of Osteopathic Medicine.
Barry Waterhouse is professor and chair of the department of cell biology and neuroscience at Rowan University where he investigates the neurobiology of the locus coruleus-norepinephrine system.
Patricia Jensen is a senior investigator at the National Institute of Environmental Health Sciences where she leads the Developmental Neurobiology Group.
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