New Approach for Investigating Neuropathic Pain by Optogenetic Stimulation of Aβ Fibers
Material below summarizes the article Optogentetic Activation of Non-nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors After Nerve Injury in Rats, published on February 5, 2018, in eNeuro and authored by Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Kohro, Keiko Tominaga, Katsuyuki Matshushita, Hidetoshi Tozaki-Saitoh, Yugo Fukazawa, Kazuhid Inoue, Hiromu Yawo, Hidemasa Furue, and Makoto Tsuda.
Somatosensory information from the periphery is conveyed to the spinal dorsal horn (SDH) via primary afferent sensory neurons. The incoming sensory information is processed by complex circuits in the SDH, integrated to projection neurons relaying to several regions of the brain.
Primary afferents are broadly divided into two classes: nociceptive (mainly unmyelinated C, and thinly myelinated alpha delta (Aδ) fibers), and non-nociceptive (myelinated alpha beta (Aβ) fibers), which respond to noxious and innocuous stimuli, respectively.
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