Neural Mechanisms Underlying Age-Related Decline in Circadian Rhythm
Material below summarizes the article Age-Related Changes in the Circadian System Unmasked by Constant Conditions, published on August 27, 2015, in eNeuro and authored by Takahiro J. Nakamura, Wataru Nakamura, Isao T. Tokuda, Takahiro Ishikawa, Takashi Kudo, Christopher S. Colwell, and Gene D. Block.
Circadian rhythms are altered by the aging process in humans and many other organisms. In people, we see this most commonly with changes in our sleep/wake cycle, with many elderly experiencing a shift to earlier bedtimes and difficulty staying asleep throughout the night. The circadian system governs the temporal patterns of processes throughout our body, and aging impacts the daily patterning of behavior, physiology, and even gene expression. In our work, we have been exploring how aging impacts the core circadian clock that drives these daily rhythms.
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