Mouse Models of Fragile X Syndrome Exhibit Subtle Deficits in Auditory Spatial Hearing
Oct 28, 2020
Material below summarizes the article Characterization of Auditory and Binaural Spatial Hearing in a Fragile X Syndrome Mouse Model, published on January 17, 2020, in eNeuro and authored by Elizabeth A. McCullagh, Shani Poleg, Nathaniel T. Greene, Molly M. Huntsman, Daniel J. Tollin, and Achim Klug.
Highlights
- Fragile X Syndrome (FXS) mice have decreased inhibition of acoustic startle responses under several auditory conditions including gaps in noise, large changes in sound source positions, and discrimination of target sounds from background noise compared to wildtype control mice.
- FXS mice took longer to respond to startling sounds in most conditions suggesting additional impairments to pathways underlying when to respond.
- FXS mouse models exhibit similar hearing impairments to humans with FXS.
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About the Contributor
Elizabeth McCullagh is an assistant professor at Oklahoma State University, where she spearheads work on Fragile X Syndrome and auditory processing difficulties.
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