Material below is adapted from the SfN Short Course Advances in Multi-Neuronal Monitoring of Brain Activity, by Douglas S. Kim, PhD, Vivek Jayaraman, PhD, Loren L. Looger, PhD, and Karel Svoboda, PhD. Short Courses are daylong scientific trainings on emerging neuroscience topics and research techniques held the day before SfN’s annual meeting.
As neuroscientists try to understand the dynamics of both large networks of neurons and single cells, new methods to monitor neuronal activity are being developed. One way to study synaptic and action potential activity is to measure intracellular calcium. Within dendritic spines, calcium transients correlate with synaptic activity, and in cell bodies, calcium signals accurately reflect action potentials (spikes).
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