From Cradle to Grave: Control of Purkinje Cell Dendrite Morphology By a Single Transcription Factor RORα
Material below summarizes the article RORα Regulates Multiple Aspects of Dendrite Development in Cerebelar Purkinje Cells In Vivo, published on September 9, 2015, in JNeurosci and authored by Yukari H. Takeo, Wataru Kakegawa, Eriko Miura, and Michisuke Yuzaki.
In the nervous system, each neuron subtype develops unique dendritic architecture that widely differs in the number of branches and the 3D orientation. Since excitatory synaptic inputs are formed mostly on dendrites, proper formation and maintenance of the dendritic architecture is fundamental for neural circuit function. Indeed, abnormal dendritic morphology is reported in brains of several neuropsychiatric disorders as well as neurodegenerative diseases. However, the mechanism of how neurons develop and maintain subtype-specific dendritic arbors is poorly understood.
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