Distinct Rules Govern Co-Modulation of Circuit Components by Two Modulators
Material below summarizes the article Distinct Co-Modulation Rules of Synapses and Voltage-Gated Currents Coordinate Interactions of Multiple Neuromodulators, published on October 3, 2018, in JNeurosci and authored by Xinping Li, Dirk Bucher, and Farzan Nadim.
All nervous systems adapt to changes in the environment and the internal state of the animal. Such flexibility is essential to producing behaviors in different contexts.
Much of this plasticity arises through the actions of neuromodulators, which actively reshape the activity and output of neuronal circuits by modifying neuronal excitability and synaptic transmission, typically by activating distinct G protein-coupled receptor-mediated pathways.
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