This event took place on September 9, 2020 and is no longer available on-demand. Read session recaps and continue the discussion in the Neuronline Community.
The formation of neuronal circuits during development and their regeneration after injury share certain similarities, but with distinct features. By understanding these processes in neural development, we may discover new therapeutic strategies to treat neuronal injuries.
During this virtual conference—organized by Marla Feller and Zhigang He—leaders in the fields of development and regeneration will discuss the current status of key studies at the cellular, molecular, and circuit level, including:
- Examples illustrating how functional circuits are built and mature during development.
- Studies highlighting regeneration in both PNS and CNS.
- Emerging frontiers in theoretical and technical studies of injury and regeneration.
- Research on rebuilding functional circuits for functional restoration and their potential translational applications.
After this virtual conference, participants are expected to have gained a broader perspective on neural development and functional restoration research.
Watch short videos from neuroscientists in the field as they describe important data and methods they use in their lab. The videos are available on Neuronline, so you can watch them before, during, or after the virtual conference. Lightning Talks are provided by Ariel Levine and Kaya Matson, Kai Liu, Melanie Samuel, and Alexandre Tiriac.
For members, including Institutional Program members:
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- Join SfN or renew your membership to receive unrestricted access to this virtual conference and other SfN member benefits.
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Development & Regeneration: Common Themes and Important Differences is intended to be applicable to individuals at all career stages. After this virtual conference, participants are expected to have gained a broader perspective on neural development and functional restoration research.
- Hear from leaders in the field discussing current research on development and regeneration across the cellular, molecular, and circuit level.
- Watch Lightning Talks, short videos accessible to attendees, featuring neuroscientists presenting on their research in the development and regeneration fields. The videos are available on Neuronline so you can watch them before, during, or after the conference. Lightning Talks will be provided by Ariel Levine and Kaya Matson, Kai Liu, Melanie Samuel, and Alexandre Tiriac.
- Ask questions and get answers from experts — each session will be accompanied by a live audio Q&A opportunity.
- Network with other attendees from around the world on Twitter using #SfNvirtual and mentioning @SfNtweets in all your posts.
- Avoid travel costs and learn about new research findings that show how we can use insight from neural development studies to inform research on therapeutic strategies to treat neuronal injuries.
- Enjoy six months of on-demand access. Can’t make it for the live day or want to watch the talks again? All sessions will be available on demand one hour after they have aired.
- Resources: Download additional information and resources chosen by speakers. Read session recaps and discuss the virtual conference in the Neuronline Community.
Click on each session title to reveal its description or download a one page version of the agenda here.
Speakers: Claire Wyart and Marla Feller
Time: 11 a.m. – noon EDT
The process of neurodevelopment has traditionally been divided into two phases: an early phase during which predetermined genetic programs guide the many steps resulting in the coarse wiring of the nervous system, and a later phase during which sensory-driven neural signaling refines these connections into adult circuits. However, there is now a large body of evidence that neural signaling and genetic programs interact to guide the maturation of neural circuits at all stages of development.
Here we will introduce two model systems — the retina and spinal cord — to describe recent progress from our labs regarding the role of early neural signaling in development, with a focus on the involvement of sensory systems and interactions with glial cells.
Speakers: Michael Sofroniew and Valeria Cavalli
Time: 12:15 – 1:15 EDT
The process of axon regeneration is guided by both the intrinsic capacity of injured neurons to activate regenerative responses after injury and by the extracellular environment in which injured axons must regrow. In the peripheral nervous system (PNS), neurons are able to activate regenerative programs, and the environment is permissive to growth and target re-innervation. By contrast, in the central nervous system (CNS), adult neurons have a poor intrinsic regenerative capacity and the tissue environment is not conducive to growth. There is now substantial evidence about how axon regrowth and plasticity are determined by interactions among neurons, glia, and immune cells.
Here we will discuss two model systems — the spinal cord and peripheral sensory neurons — to describe recent progress from our lab and others regarding the roles of neuron-cell-autonomous mechanisms and the role of glial cells in regenerative growth.
Speakers: Karthik Shekhar and Kristian Franze
Time: 1:30 – 2:30 p.m. EDT
Injuries to adult mammalian CNS neurons usually lead to permanent damage. As functional recovery of neurons cannot still be fully promoted, new approaches are needed to illuminate currently unknown processes involved in regulating axon growth and regeneration and identifying potential therapeutic targets.
In this session, we will introduce methods to investigate mechanical signals such as tissue stiffness and transcriptomic states at single cell resolution to investigate currently understudied important aspects of CNS development and regeneration.
Speakers: Mark Tuszynski and Susan Harkema
Time: 2:45 – 3:45 p.m. EDT
Restoration of function after CNS injury is a complex and ongoing effort that will ultimately need to draw on several repair mechanisms to support detectable functional benefit in humans. This session will describe key challenges to promoting functional recovery, and the status of early efforts to promote human recovery.
Mark Tuszynski will discuss the challenge of identifying the timing of neural repair interventions such as stem cell therapies in humans. Susan Harkema will describe an ongoing effort to promote plasticity of spared systems through focused rehabilitation in humans after spinal cord injury.
Review SfN’s Code of Conduct, rules for virtual events in the Digital Learning Community Guidelines, and communications policies regarding dissemination of unpublished scientific data, listed below. SfN asks that conference attendees respect the sensitivity of information and data being presented that are not yet available to the public by following these guidelines:
- Do not capture or publicly share details of any unpublished data presented.
- If you are unsure whether data is unpublished, check with the presenter.
- Respect presenters' wishes if they indicate that the information presented is not to be shared.
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SfN webinars can be watched on-demand if someone is unable to attend the live broadcast.
When will the conference open? The conference will open for registrants on Wednesday, September 9, at 10:45 a.m. Sessions will run live from 11 a.m. to 3:45 p.m. EDT.
How long is the conference available on demand? This conference will be available on demand for six months after the live broadcast.
How do I access the conference on the live day and on demand? To enter the conference either live or on demand, use the login button found in your registration confirmation email and enter your email address. Your login information should not be shared and is unique to you. You may access the conference as many times as you would like.
How do I find my receipt for the virtual conference? Receipt information is included in your registration confirmation email.