Join this interactive session as Tim Spellman discusses his paper, “Choice Behaviors and Prefrontal–Hippocampal Coupling Are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders”, with JNeurosci Editor-in-Chief Sabine Kastner. Attendees can submit questions at registration and live during the webinar.
Below is the significance statement of the paper published March 5, 2025, in JNeurosci and authored by Hailey L. Rosenblum, SuHyeong Kim, John J. Stout, Anna Y. Klintsova, and Amy L. Griffin.
Fetal alcohol spectrum disorders (FASDs) occur at an alarmingly high rate worldwide. Prenatal alcohol exposure (AE) leads to significant perturbations in brain circuitry that are accompanied by cognitive deficits, including disrupted executive functioning and working memory. These deficits stem from structural changes within several key brain regions including the prefrontal cortex and hippocampus. To better understand the cognitive deficits observed in FASD patients, we employed a rodent model of AE during the third trimester, a period when these regions are especially vulnerable to alcohol-induced damage. We show that AE disrupts choice behaviors and prefrontal–hippocampal functional connectivity during a working memory task, identifying the prefrontal–hippocampal network as a potential therapeutic target in FASD treatment.
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