Material below is adapted from the SfN Short Course Alzheimer’s Disease Genetics: From the Bench to the Clinic, by Celeste M. Karch, PhD, Carlos Cruchaga, PhD, and Alison Goate, DPhil. Short Courses are daylong scientific trainings on emerging neuroscience topics and research techniques held the day before SfN’s annual meeting.
The symptoms characterizing Alzheimer’s disease — memory loss and general cognitive decline — appear to derive from physical changes within the brain including amyloid plaque accumulation in the extracellular spaces, tangled fibrils of tau proteins within neural cells, and gross atrophy.
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