Material below summarizes the article Adenosine Shifts Plasticity Regimes between Associative and Homeostatic by Modulating Heterosynaptic Changes, published on February 8, 2017, in JNeurosci and authored by Nicholas M. Bannon, Marina Chistiakova, Jen-Yung Chen, Maxim Bazhenov, and Maxim Volgushev.
Plasticity is a universal property of synapses, vital for fundamental operations of the nervous system. The Hebbian rule for associative plasticity postulates that inputs that consistently take part in firing of a postsynaptic neuron — that is, inputs that produce postsynaptic potentials that closely precede spikes and thus contribute to their generation — should be potentiated. By extension, inputs whose activity does not help drive firing should be depressed.
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