Material below is adapted from the SfN Short Course Synapse Elimination and Learning Rules Coregulated by Major Histocompatibility Class I Protein H2-Db, by Hanmi Lee, PhD, Lowry A. Kirkby, PhD, Barbara K. Brott, PhD, Jaimie D. Adelson, PhD, Sarah Cheng, BS, Marla B. Feller, PhD, Akash Datwani, PhD, and Carla J. Shatz, PhD. Short Courses are daylong scientific trainings on emerging neuroscience topics and research techniques held the day before SfN’s annual meeting.
Major histocompatibility complex class I (MHCI) proteins occur on nearly all vertebrate cells and function as a marquee for the immune system, displaying bits of non-self proteins from the cell’s cytosol on its surface. Now, researchers have shown in mice that a common MCHI protein, H2-Db, is required for shaping the synapses during the development of the retinogeniculate system.
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