Material below summarizes the article SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens, published on August 10, 2016, in JNeurosci and authored by Hee-Dae Kim, Jennifer Hesterman, Tanessa Call, Samantha Magazu, Elizabeth Keeley, Kristyna Armenta, Hope Kronman, Rachael L. Neve, Eric J. Nestler, and Deveroux Ferguson.
Major depressive disorder (MDD) is a significant cause of disability with few effective treatments. More than 350 million individuals worldwide suffer from depression. In the United States, approximately 30 million individuals suffer from depression, which accounts for approximately $60 billion dollars lost in annual productivity. Current treatment approaches for depression are largely ineffective and leave more than 50 percent of patients symptomatic.
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