It is often claimed that tools are embodied by their user, but whether the brain actually repurposes its body-based computations to perform similar tasks with tools is not known. A fundamental computation for localizing touch on the body is trilateration. Here, the location of touch on a limb is computed by integrating estimates of the distance between sensory input and its boundaries (e.g., elbow and wrist of the forearm). As evidence of this computational mechanism, tactile localization on a limb is most precise near its boundaries and lowest in the middle. Here, we show that the brain repurposes trilateration to localize touch on a tool, despite large differences in initial sensory input compared with touch on the body. In a large sample of participants, we found that localizing touch on a tool produced the signature of trilateration, with highest precision close to the base and tip of the tool. A computational model of trilateration provided a good fit to the observed localization behavior. To further ...

Mitochondria are integrative hubs central to cellular adaptive pathways. Such pathways are critical in highly differentiated postmitotic neurons, the plasticity of which sustains brain function. Consequently, defects in mitochondria and in their dynamics appear instrumental in neurodegenerative diseases and may also participate in cognitive impairments. To directly test this hypothesis, we analyzed cognitive performances in a mouse mitochondria-based disease model, because of haploinsufficiency in the mitochondrial optic atrophy type 1 (OPA1) protein involved in mitochondrial dynamics. In males, we evaluated adult hippocampal neurogenesis parameters using immunohistochemistry. We performed a battery of tests to assess basal behavioral characteristics and cognitive performances, and tested putative treatments. While in dominant optic atrophy (DOA) mouse models, the known main symptoms are late onset visual deficits, we discovered early impairments in hippocampus-dependent spatial memory attributable to defe...

Working memory (WM) can maintain sequential and concurrent information, and the load enhances the γ band oscillation during the delay period. To provide a unified account for these phenomena in working memory, we investigated a continuous network model consisting of pyramidal cells, high-threshold fast-spiking interneurons (FS), and low-threshold nonfast-spiking interneurons (nFS) for working memory of sequential and concurrent directional cues. Our model exhibits the γ (30–100 Hz) and β (10–30 Hz) band oscillation during the retention of both concurrent cues and sequential cues. We found that the β oscillation results from the interaction between pyramidal cells and nFS, whereas the γ oscillation emerges from the interaction between pyramidal cells and FS because of the strong excitation elicited by cue presentation, shedding light on the mechanism underlying the enhancement of γ power in many cognitive executions.

During early development, neurons in the brain often form excess synaptic connections. Later, they strengthen some connections while eliminating others to build functional neuronal circuits. In the olfactory bulb, a mitral cell initially extends multiple dendrites to multiple glomeruli but eventually forms a single primary dendrite through the activity-dependent dendrite pruning process. Recent studies have reported that microglia facilitate synapse pruning during the circuit remodeling in some systems. It has remained unclear whether microglia are involved in the activity-dependent dendrite pruning in the developing brains. Here, we examined whether microglia are required for the developmental dendrite pruning of mitral cells in mice. To deplete microglia in the fetal brain, we treated mice with a colony-stimulating factor 1 receptor (CSF1R) inhibitor, PLX5622, from pregnancy. Microglia were reduced by >90% in mice treated with PLX5622. However, dendrite pruning of mitral cells was not significantly affec...

Most human navigation studies in MRI rely on virtual navigation. However, the necessary supine position in MRI makes it fundamentally different from daily ecological navigation. Nonetheless, until now, no study has assessed whether differences in physical body orientation (BO) affect participants’ experienced BO during virtual navigation. Here, combining an immersive virtual reality navigation task with subjective BO measures and implicit behavioral measures, we demonstrate that physical BO (either standing or supine) modulates experienced BO. Also, we show that standing upright BO is preferred during spatial navigation: participants were more likely to experience a standing BO and were better at spatial navigation when standing upright. Importantly, we report that showing a supine virtual agent reduces the conflict between the preferred BO and physical supine BO. Our study provides critical, but missing, information regarding experienced BO during virtual navigation, which should be considered cautiously ...

The sensory system allows humans to not only explore the world but also to monitor their own bodies for injury and disease through the sensation of pain. After an injury, signals from the injured tissues travel along the nerves, entering the central nervous system through the spinal cord before going into the brain. In the acute stages, pain modulates behavior in ways that promote healing, including limiting mobility. In most cases, pain resolves as the injury heals, but, in some cases, pain persists and becomes chronic. Chronic pain is a massive issue, affecting up to 20% of Americans and leading to reduced quality of life for those affected. The factors leading to chronic pain are complex, and new approaches are needed to improve understanding of chronic pain and find effective treatments. In the current issue of eNeuro , Haroun et al. (2023) use a new approach to transiently silence sensory neurons in uninjured mice as well as mouse models of acute and chronic pain using a technique known as chemogenet...

Brains implement some of the most complex functions of living systems including intelligence, decision-making, learning, and sentience, which is the capacity for subjective experience. To better understand these and other cognitive functions, neuroscientists have meticulously delineated the brain’s microcircuitry and pathways to relate mental phenomena with discrete neural substrates. One of the driving forces behind what has become an ever-expanding literature on functional neuroanatomy is the longstanding assumption that all mental actions and states can be localized, mapped, or otherwise attributed to specific configurations of brain matter. Consistent with this assumption, by selectively damaging or stimulating brain regions, one could suppress or evoke cognitive or behavioral responses that confirmed suspected structure-function relationships. While this approach has not helped explain why mind emerges from matter, its historical success is a crowning achievement for the field of cognitive neuroscienc...

Because of the legalization of Cannabis in many jurisdictions and the trend of increasing Δ9-tetrahydrocannabinol (THC) content in Cannabis products, an urgent need exists to understand the impact of Cannabis use during pregnancy on fetal neurodevelopment and behavior. To this end, we exposed female Sprague Dawley rats to Cannabis smoke daily from gestational day 6 to 20 or room air. Maternal reproductive parameters, offspring behavior, and gene expression in the offspring amygdala were assessed. Body temperature was decreased in dams following smoke exposure and more fecal boli were observed in the chambers before and after smoke exposure in dams exposed to smoke. Maternal weight gain, food intake, gestational length, litter number, and litter weight were not altered by exposure to Cannabis smoke. A significant increase in the male-to-female ratio was noted in the Cannabis -exposed litters. In adulthood, male and female Cannabis smoke-exposed offspring explored the inner zone of an open field significantl...

The detection of a single photon by a rod photoreceptor is limited by two sources of physiological noise, called discrete and continuous noise. Discrete noise occurs as intermittent current deflections with a waveform very similar to that of the single-photon response to real light and is thought to be produced by spontaneous activation of rhodopsin. Continuous noise occurs as random and continuous fluctuations in outer-segment current and is usually attributed to some intermediate in the phototransduction cascade. To confirm the origin of these noise sources, we have recorded from retinas of mouse lines with rods having reduced levels of rhodopsin, transducin, or phosphodiesterase. We show that the rate of discrete noise is diminished in proportion to the decrease in rhodopsin concentration, and that continuous noise is independent of transducin concentration but clearly elevated when the level of phosphodiesterase is reduced. Our experiments provide new molecular evidence that discrete noise is indeed pr...

I am always marveled by the brain’s vast capabilities. Each discovery, each revelation, seems to open a door only to reveal myriad others yet unopened. The brain, with its vast intricacies, consistently reminds us that its complexity transcends the limits of our imagination. It is in this spirit that I wish to introduce “Brain Mysteries: Complexity Beyond Imagination” in eNeuro . All neuroscientists have been contributing for decades to the mapping of brain networks and to the unraveling of its codes. While every stride has been fruitful in terms …