Glymphatic transport in rodents has primarily been studied using cisterna magna cannulation (CMC), a minimally invasive method for cerebrospinal fluid (CSF) tracers infusion. However, CMC is suboptimal due to the lack of bony structures to stabilize the cannula, leading to potential movement artifacts. Here, we present an alternative approach involving chronic cannulation of the lateral ventricles of mice for CSF tracer delivery. A direct comparison demonstrated that intraventricular cannulation (IVC) reproduces CMC results in vivo, including perivascular labeling of the middle cerebral artery, which was further confirmed by ex vivo analysis. IVC enables tracer infusion in awake mice, facilitating glymphatic transport studies in conjunction with behavioral assessments that were previously unattainable. Additionally, IVC supports repeated infusions in awake animals, offering the potential to reduce the number of experimental animals required. This study establishes IVC as a robust alternative for studying g...

The genetic role and specific effects of primary familial cerebral calcification (PFBC) are still unclear. We aim to analyze bibliometric features in studies related to PFBC, investigate variant detection rates in patients with brain calcifications, and examine the phenotypic characteristics of PFBC patients. A comprehensive search of studies on the genetic effects of PFBC up until December 31, 2024, was conducted across Web of Science, PubMed, Embase, and Scopus. A random-effects meta-analysis combined variant detection rates for genes SLC20A2 , PDGFRB , PDGFB , XPR1 , MYORG , JAM2 , CMPK2 , and NAA60 . Data on total calcification scores (TCS), age of onset, and the prevalence of various phenotypes in PFBC patients were also aggregated. Publication bias was assessed using Egger's linear regression, and a leave-one-out sensitivity analysis was performed. Of 1,267 records, 224 were included in the bibliometric analysis. Keywords “primary familial brain calcification” and “ SLC20A2 ” were most prominent. Eig...

What can neuroscience tell us about ethics? Some say nothing – ethics is a normative discipline that concerns the way the world should be, while neuroscience is normatively insignificant: it is a descriptive science which tells us about the way the world is. This seems in line with what is sometimes called “Hume’s Law”, the claim that one cannot derive an ought from an is. This claim is contentious and its scope unclear, but it certainly does seem true of demonstrative arguments, at the least. Neuroethics, by its name, however, seems to suggest that neuroscience is relevant for ethical thought, and indeed some have taken it to be a fact that neuroscience has delivered ethical consequences. It seems to me that there is some confusion about this issue, and so here I’d like to clarify the ways in which I think neuroscience can be relevant to ethics.

TrainingSpace (TS) is an online hub that aims to make neuroscience educational materials more accessible to the global neuroscience community. As a hub, TS provides users with access to: Multimedia educational content from courses, conference lectures, and laboratory exercises from some of the world’s leading neuroscience institutes and societies. Study tracks to facilitate self-guided study. Tutorials on tools and open science resources for neuroscience research. A Q&A forum. A neuroscience encyclopedia that provides users with access to over 1,000,000 publicly available datasets as well as links to literature references and scientific abstracts. Topics currently included in TS include: general neuroscience, clinical neuroscience, computational neuroscience, neuroinformatics, computer science, data science, and open science. All courses and conference lectures in TS include a general description, topics covered, links to prerequisite courses if applicable, and links to software described in or required for the course, as well as links to the next lecture in the course or more advanced related courses. To learn more about TrainingSpace, visit: https://training.incf.org

Effects of early life stress are found to be dependent on many factors, including sex and genetic background, the age of early exposure, and the age and context within which the long-term impact is examined. This webinar will discuss the resultant high individual variability of early life stress and its impact on coping abilities and cognitive functions later in life.

Much of science advocacy is local by nature, but it also has tremendous potential to bring neuroscientists together on a global scale. In this episode of History of SfN: 50th Anniversary, Bill Martin, the president and chief operating officer of Blackthorn Therapeutics, traces the evolution of SfN’s role in global advocacy efforts throughout his time on its Government and Public Affairs Committee and continued involvement with the Society.

In this episode of History of SfN: 50th Anniversary, Bernice Grafstein, Vincent and Brooke Astor Distinguished Professor in Neuroscience at Cornell University, Trustee and Vice-President of the Grass Foundation — and the first female president of the Society for Neuroscience — recounts how the formation of the Society for Neuroscience brought together neuroscientists of diverse backgrounds.

In its 50 years, the Society for Neuroscience has become an international society representing the interests of scientists from diverse backgrounds across the globe. In this episode of History of SfN: 50th Anniversary, Mickey Goldberg, David Mahoney Professor of Brain and Behavior at Columbia University, and a past president of the Society for Neuroscience, describes how the Society and meeting have evolved, including through the digitization of abstract submissions. History of SfN: 50th Anniversary is a limited series podcast highlighting stories from the history of the Society for Neuroscience, recounting groundbreaking moments in the growth of the Society from the perspectives of current, past, and future leaders. Alongside his scientific background and time as SfN president, Goldberg also offers a look at his involvement with science outreach and the importance of outreach to building public trust in science.

In this episode of History of SfN: 50th Anniversary, Marder, Victor and Gwendolyn Beinfield Professor of Neuroscience at Brandeis University and a past president of the Society for Neuroscience, expands on this thought, sharing details from her time on SfN’s Program Committee and about the evolution of annual meeting programs, as well as her award-winning research on motor neurons.

In this episode of History of SfN: 50th Anniversary, Marina Picciotto, Charles B.G. Murphy Professor of Psychiatry at Yale University and the editor-in-chief of JNeurosci, notes how the journal has evolved in its nearly 40 years to mirror the changing ways in which research is shared.