In this presentation, Martin Kampmann will introduce functional genomics approaches in iPSC-derived neurons and glia. Specifically, Kampmann will: - Cover CRISPRi (interference) and CRISPRa (activation) control of gene expression. - Describe how to implement CRISPRi/a in iPSC-derived cells. - Introduce large-scale genetic screens based on survival, fluorescent readouts of cell function, single-cell RNA sequencing, and high-content imaging - Use of functional genomics to understand mechanisms underlying disease-linked genes and potential therapeutic strategies.