When presented with a periodic stimulus, humans spontaneously adjust their movements from reacting to predicting the timing of its arrival, but little is known about how this sensorimotor adaptation changes across development. To investigate this, we analyzed saccade behavior in 114 healthy humans (ages 6–24 years) performing the visual metronome task, who were instructed to move their eyes in time with a visual target that alternated between two known locations at a fixed rate, and we compared their behavior to performance in a random task, where target onsets were randomized across five interstimulus intervals (ISIs) and thus the timing of appearance was unknown. Saccades initiated before registration of the visual target, thus in anticipation of its appearance, were labeled predictive [saccade reaction time (SRT) < 90 ms] and saccades that were made in reaction to its appearance were labeled reactive (SRT > 90 ms). Eye-tracking behavior including saccadic metrics (e.g., peak velocity, amplitude), pupil ...

Sarael Alcauter is an assistant professor in the department of behavioral and cognitive neurobiology at the Institute of Neurobiology, National Autonomous University of Mexico (UNAM).

Sergei Kirov is a professor in the department of neurosurgery and brain and the Behavior Discovery Institute at the Medical College of Georgia.

Sheena Josselyn is a senior scientist in The Hospital for Sick Children’s Neurosciences and Mental Health Program.

Sho Aoki is a postdoctoral scholar at the Okinawa Institute of Science and Technology.

Silke Nuber and coworkers generated and deeply characterized numerous transgenic rodent models to study PD and related disorders, including the first inducible α-synuclein (αS) transgenic mice, humanized BAC-wildtype human αS tg rat models.

Sridevi Venkatesan is a graduate of the Indian Institute of Science, Bangalore, in India, and is currently a third-year PhD student in the department of physiology at the University of Toronto.

Stephanie Perez is a postdoctoral fellow at the University of Texas Health Science Center at San Antonio.

Stephen Chang is a postdoctoral research fellow in Kyle Smith’s laboratory at Dartmouth College.

Stephen Dewhurst is the associate vice president for health sciences research and vice dean for research at the University of Rochester School of Medicine and Dentistry.