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Neuronline is a benefit of SfN membership. Renew your membership now to make sure you don’t lose access.

Marina Picciotto (outgoing JNeurosci Editor-in-Chief and SfN President-Elect) and Sabine Kastner (incoming JNeurosci Editor-in-Chief) discuss their careers along with the history and future of The Journal of Neuroscience. Check out the Reviewer Mentor Program.

Neuronline is a benefit of SfN membership. Renew your membership now to make sure you don’t lose access.

Neuronline is a benefit of SfN membership. Renew your membership now to make sure you don’t lose access.

Neuronline is a benefit of SfN membership. Renew your membership now to make sure you don’t lose access.

Neuronline is a benefit of SfN membership. Renew your membership now to make sure you don’t lose access.

Vestibular dysfunction constitutes a major medical concern, and regeneration of hair cells (HC) is a primary target of gene therapy aimed at restoring vestibular functions. Thus far, therapeutic trials in animal models targeting vestibular loss associated with genetic diseases have yielded variable and partial results, and the functional identity and quantity of HCs required to restore minimal or normal vestibular function remain undefined. Indeed, direct comparisons between structural pathology and quantitative assessments of vestibular dysfunctions are lacking in humans and are rather limited in animal models, representing a significant gap in current knowledge. Here, we present an innovative methodology to bridge the gap between HC integrity and functional vestibular loss in individual mice of either sex. Gradual vestibular deficits were induced through a dose-dependent ototoxic lesion, quantified with canal or utricular-specific vestibulo-ocular reflex tests, and were then correlated in all individuals...

Galanin-expressing neurons in the ventrolateral preoptic area (VLPOgalanin) are active during sleep and play an important role regulating non-rapid eye movement (NREM) sleep. It is generally believed that VLPOgalanin neurons promote sleep via inhibitory actions in arousal promoting regions of the brain. Histaminergic neurons are a population of wake-active neurons that receive strong projections from the sleep-active VLPOgalanin neurons. However, the ability of galanin to influence the activity of histaminergic neurons has received limited attention. Here, using whole-cell patch clamp electrophysiological recordings from genetically identified histaminergic neurons in male mice, we explore the mechanisms by which galanin influences histaminergic neuron electrical excitability. Our results reveal that galanin is a powerful inhibitor of histaminergic neuron activity and demonstrate that the inhibitory effects of galanin are mediated by galanin receptor 1 (GALR1) and the subsequent opening of G protein-couple...