Learn how implicit bias, often subtle and based on cultural stereotypes, influences the recruitment, promotion, and retention of women and diverse faculty in higher education — and what you can do to change this.

Kenneth Maynard is a global program leader, central nervous system, at Takeda Pharmaceuticals. In a recent interview, he discussed a variety of topics, including his own career path and how others can work in the pharmaceutical industry.

As the knowledge base in neuroscience continues to expand, educators need timely resources to engage their students. Educational Resources in Neuroscience (ERIN), a web portal developed by the Society for Neuroscience (SfN) with funding from the National Science Foundation (NSF), is an invaluable tool to help undergraduate, graduate, and clinical education professors find state-of-the art resources.

Your science affects society. So how can you get the public to understand and interact with the most important parts of your research? Through lay writing, or writing for a science-interested public, which makes the research you care about accessible.

Conducting quality peer reviews are important — for the authors, journals, and scientific research. Here’s what you should know about how to approach your peer review responsibilities.

Ischemic stroke (IS) poses a serious threat to patient survival. The inhibition of ferroptosis can effectively alleviate ischemia-reperfusion (I/R) injury, suggesting potential targets in the ferroptosis pathway for the treatment of ischemic stroke. In this study, MCAO/R mice and OGD/R-induced HT22 cell were constructed. It was found that Baicalein decreased ROS, MDA, and Fe2+ levels, upregulated GSH levels, and enhanced the expression of ferroptosis-related proteins (GPX4 and SLC7A11), downregulated the expression of pro-apoptotic proteins (Bax, cytochrome c, and cleaved caspase-3), and upregulated the expression of an anti-apoptotic protein (Bcl-2), ameliorating cerebral I/R injury. In animal and cell models, SIRT6 is downregulated, and FOXA2 expression and acetylation levels are abnormally upregulated. SIRT6 inhibited FOXA2 expression and acetylation. Baicalein promoted FOXA2 deacetylation by upregulating SIRT6 expression. FOXA2 transcriptionally inhibits SLC7A11 expression. In Conclusion, Baicalein inh...

Despite decades of preclinical investigation, there remains limited understanding of the etiology and biological underpinnings of anxiety disorders. Sensitivity to potential threat is characteristic of anxiety-like behavior in humans and rodents, but traditional rodent behavioral tasks aimed to assess threat responsiveness lack translational value, especially with regards to emotionally valenced stimuli. Therefore, development of novel preclinical approaches to serve as analogues to patient assessments is needed. In humans, the fearful face task is widely used to test responsiveness to socially communicated threat signals. In rats, ultrasonic vocalizations (USVs) are analogous social cues associated with positive or negative affective states that can elicit behavioral changes in the receiver. It is therefore likely that when rats hear aversive alarm call USVs (22kHz) they evoke translatable changes in brain activity comparable to the fearful face task. We used functional magnetic resonance imaging in male ...

Human and mouse dorsal root ganglia (hDRG and mDRG) neurons are important tools in understanding the molecular and electrophysiological mechanisms that underlie nociception and drive pain behaviors. One of the simplest differences in firing phenotypes is that neurons are single-firing (exhibit only one action potential) or multi-firing (exhibit 2 or more action potentials). To determine if single- and multi-firing hDRG neurons exhibit differences in intrinsic properties, firing phenotypes, and AP waveform properties, and if these properties could be used to predict multi-firing, we measured 22 electrophysiological properties by whole-cell patch-clamp electrophysiology of 94 hDRG neurons from 6 male and 4 female donors. We then analyzed the data using several machine learning models to determine if these properties could be used to predict multi-firing. We used 1000 iterations of Monte Carlo Cross Validation to split the data into different train and test sets and tested the Logistic Regression, k-Nearest N...

A career in science writing allows you to explore the newest and most exciting discoveries in neuroscience and use your passion for writing to explain them to the world. Greg Miller discusses how his jobs at Science and Wired Magazine led to amazing opportunities to travel around the world and meet fascinating people from every walk of life.

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